Structural basis of the trans-membrane chemo-receptors involved in bacterial signal transduction

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In this study, we revealed the ligand recognition mechanism of Tsr, a bacterial chemo-receptor for serine, and Tcp, that for citrate, by X-ray crystallography, mutational analysis and the ITC measurements. We also elucidated the ligand binding mechanisms of Mlp24 and Mlp37, bacterial chemo-receptors with PAS-like domains, from the crystal structures of Mlp24 and Mlp37 with or without ligands and following mutational analyses.