Studies on comprehensive physiological functions of novel exogenous neuromodulating peptides

我们研究了低分子量肽与神经系统之间的相互作用。基于强效抗焦虑肽的构效关系，我们发现了胃肠道蛋白酶从食物蛋白中释放的新型抗焦虑样肽。食源性多肽可能是外源性神经调节因子之一。我们还发现，具有神经调节活性的低分子肽有时会表现出睡眠诱导活性，改变食物摄入和调节能量代谢。

We investigated interaction between low-molecular weight peptides and the nervous system. We found novel anxiolytic-like peptides released from food proteins by gastrointestinal proteases, based on structure-activity relationship of potent anxiolytic peptides. The food-derived peptides may be one of exogenous neuromodulating factors. We also found that low-molecular peptides with neuromodulating activities sometimes exhibited sleep inducting activity, changed food intake, and modulated energy metabolism.