Development of a non-destructive detector of unsuitable chicken eggs in influenza vaccine production

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In Japan, fertilized chicken eggs are used to produce influenza vaccines. However, some eggs do not develop and then contaminate the vaccine stock solution, which causes large economic losses and raises health concerns. Therefore, a non-destructive test that allows distinction of normal and unsuitable chicken eggs was developed, using visible and near-infrared (VNIR) spectroscopy and a light-emitting diode (LED) light source.Linear discriminant analysis was applied using wavelength absorbance data to distinguish between normal and unsuitable eggs, and all of the optical absorbance values of the normal eggs were found to be higher than those of unsuitable eggs. The rate of discrimination between the two types of eggs exceeded 97% when linear discriminant analysis and two wavelengths in the visible light range were used.