Regulation by nesfatin and oxytocin of feeding, metabolism and circadian rhythm, as a basis for treating life style-related diseases

Nesfatin-1 mRNA在下丘脑室旁核（PVN）的表达呈现昼夜节律，并伴有光相上升，从而驱动大鼠的昼夜摄食节律。nesfatin-1节律障碍导致摄食节律障碍、嗜食和肥胖。在光照期补充nesfatin-1可改善这些代谢紊乱。PNV nesfatin-1神经元直接被食物诱发因子、葡萄糖和胰岛素以及光诱导神经肽PACAP激活，并作为下游效应物向PVN催产素神经元发出信号。外周注射催产素可纠正高脂肪饮食喂养的肥胖综合征小鼠的贪食、肥胖、高血糖和脂肪肝。这些影响部分是由迷走传入神经向大脑传递的信号介导的。这些结果为治疗人类肥胖提供了基础。

Nesfatin-1 mRNA expression in the paraventricular nucleus (PVN) of hypothalamus exhibits circadian rhythm with light phase rise, which drives circadian feeding rhythm in rats,. Impairment of the nesfatin-1 rhythm causes impairment of feeding rhythm, hyperphagia and obesity. Supplementation of nesfatin-1 in light phase ameliorates these metabolic disorders.The PNV nesfatin-1 neuron is directly activated by meal-evoked factors, glucose and insulin, and by light-induced neuropeptide PACAP, while it signals to the PVN oxytocin neuron as the downstream effector.Peripheral administration of oxytocin corrects hyperphagia, obesity, hyperglycemia and fatty liver in high fat diet-fed mice with obesity syndrome. These effects are partly mediated by the signal transfer to the brain via vagal afferent nerves. These results provide a basis for the treatment of human obesity.