Integrated approach for identification of tumor-suppressive microRNAs and clinical application to miRNA-based therapy for cancers

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The aim of this study is to identify tumor-suppressive microRNAs (miRNAs) and their direct targets, which potentially contribute to the development of clinical application to miRNA-based therapy for cancers. Actually, in this study, three tumor-suppressive miRNAs, one EMT-suppressive miRNA, and their direct targets were identified through our integrated approach using function- and methylation-based screenings. Moreover, we demonstrated here the great potential of double-stranded RNAs (dsRNA) mimicking sequences of tumor-suppressive miRNAs to be applied to miRNA-based therapy for cancers.