Human natural helper cells and its involvement in diseases

人类天然辅助细胞及其与疾病的关系

• 批准号: 23390086
• 负责人: YAMADA TAKETO
• 金额: $ 12.65万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390086/
• 关键词: 病理学; 免疫学; メタボリック症候群; 自然免疫; アレルギー・ぜんそく

Pathophysiological examinations of human innate immunology-related natural helper (NH) cells in fat-associated lymphoid cluster (LALC) were done using autopsy cases. FALCs in adipose tissues of total body were analyzed anatomically and histologically, consequently FALC was dominantly located in mesentery and NH cells were most frequent in mesentery as compared to omentum, fat capsule of kidney, genitalia, and retroperitoneum. Hunan NH cells prepared from human mesentery had the same patterns of gene expressions and similar kinds of cytokine production to murine NH cells. Human NH cells labeled with CSFE were transplanted in NOG mice. As a result human NH cells lodged in murine adipose tissues and produced human IL-5 and IL-13 constitutively. The area of FALC and NH cell number was decreased in mesentery of cases with diabetes mellitus and metabolic syndrome as compared to control cases.

对尸检病例脂肪相关淋巴簇（LALC）中的天然免疫相关自然辅助（NH）细胞进行了病理生理学检查。对全身脂肪组织中的NH细胞进行了解剖学和组织学分析，结果表明，NH细胞主要位于肠系膜，NH细胞最常见于肠系膜，而网膜、肾脏脂肪囊、生殖器和腹膜后。从人肠系膜制备的湖南NH细胞与小鼠NH细胞具有相同的基因表达模式和相似的细胞因子产生。将CSFE标记的人NH细胞移植到NOG小鼠中。结果，人NH细胞驻留在鼠脂肪组织中并组成性地产生人IL-5和IL-13。糖尿病合并代谢综合征患者肠系膜上NHC面积和NH细胞数均较对照组减少。

项目成果

The Pathogenesis of pulmonary alveolar proteinosis in PI3K deficient mice

PI3K缺陷小鼠肺泡蛋白沉积症的发病机制

• 发表时间: 2013
• 作者: Nagai S;Yoshizawa A;Baba Y;Yamada T;Nishimura T;Koyasu S
• 通讯作者: Koyasu S

Change in beta cell and alpha cell mass in Japanese obese individuals.

日本肥胖者β细胞和α细胞质量的变化。

• 发表时间: 2012
• 作者: Furuhashi T;Saito C;Torii K;Nishida E;Yamazaki S;Morita A;鏡雅代など;Kou K
• 通讯作者: Kou K

A mimic of viral dsRNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse

病毒 dsRNA 的模拟物在调节性 T 细胞缺陷的自身免疫糖尿病小鼠中引发暴发性 1 型糖尿病样综合征

• 发表时间: 2011
• 期刊: Journal of Immunology
• 影响因子: 4.4
• 作者: Tada A;Shimada A;Yamada T;Oikawa Y;Yamada Y;Okubo Y;Irie J;Bluestone JA;Itoh H
• 通讯作者: Itoh H

Impairment of cell growth by down regulation of NCAP2 gene transcription mediated with nuclear transported CD26 using humanized anti-CD26 monoclonal antibody.

使用人源化抗 CD26 单克隆抗体，通过核转运 CD26 介导的 NCAP2 基因转录下调来损害细胞生长。

• 发表时间: 2012
• 作者: 山崎小百合;森田明理;鏡雅代;Yamada T
• 通讯作者: Yamada T

Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice

• DOI: 10.1172/jci57379
• 发表时间: 2011-09-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Takahashi, Hayato;Kouno, Michiyoshi;Amagai, Masayuki
• 通讯作者: Amagai, Masayuki