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Increases in Tryptophan-kynurenine pathway metabolism following interferon-induced depression

Increases in Tryptophan-kynurenine pathway metabolism following interferon-induced depression
干扰素诱导的抑郁症后色氨酸-犬尿氨酸途径代谢增加
批准号:
23390149
负责人:
SAITO KUNIAKI
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
Increases in L-tryptophhn (TRP) to L-kynurenine (KYN) pathway metabolism were found in interferon (IFN) treated-HCV patients with depressive symptoms. Further, mice with Interferon (IFN) gene transfection induced indoleamine 2,3-dioxygenase (IDO1) , resulting marked increase in TRP to KYN pathway metabolites, which well correlated with depression. The blockade of IDO1 activation prevented the development of depressive-like behavior.
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Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2.
获得的白血病细胞对ARAC的耐药性与醛脱氢酶1家族成员A2的上调有关。
DOI: 10.1016/j.exphem.2013.03.004
发表时间: 2013-07
期刊: EXPERIMENTAL HEMATOLOGY
影响因子: 2.6
作者: [Kawasoe, Misaki, Yamamoto, Yasuko, Okawa, Katsuya, Funato, Tadao, Takeda, Mayu, Hara, Takeshi, Tsurumi, Hisashi, Moriwaki, Hisataka, Arioka, Yuko, Takemura, Masao, Matsunami, Hidetoshi, Markey, Sanford P., Saito, Kuniaki]
通讯作者: Saito, Kuniaki
Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity and gene expression of in doleamine 2, 3-dioxygenase 1
拉丹烷型二萜,来自日本传统食品 myoga 的成分,抑制多尔胺 2, 3-双加氧酶 1 的酶活性和基因表达
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Imai, R Yamamoto, Y Yamamoto, Y Katayan agi, R Fukutomi, M Abe, Y Ozawa, K Saito]
通讯作者: K Saito
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.3892/ol.2012.761
发表时间: 2012-09
期刊: Oncology letters
影响因子: 2.9
作者: [Kengo Ogawa;T. Hara;M. Shimizu;J. Nagano;T. Ohno;Masato Hoshi;Hiroyasu Ito;H. Tsurumi;Kuniaki Saito;M. Seishima;H. Moriwaki]
通讯作者: Kengo Ogawa;T. Hara;M. Shimizu;J. Nagano;T. Ohno;Masato Hoshi;Hiroyasu Ito;H. Tsurumi;Kuniaki Saito;M. Seishima;H. Moriwaki
15
    A Micro-Comparative Study on the Impact of Japanese Land Reform on Farmers
    Genome-wide epigenetic analysis of glioma and glioma stem-like cells
    • 批准号:
      26462177
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2014
    • 负责人:
      SAITO KUNIAKI
    • 依托单位:
    海外基金