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Examination of the pathogenesis of epigenetics of virus infection for allergic diseases and development of preventive methods for it

Examination of the pathogenesis of epigenetics of virus infection for allergic diseases and development of preventive methods for it
过敏性疾病病毒感染表观遗传学发病机制研究及预防方法开发
批准号:
23390160
负责人:
NAKAMURA HIROYUKI
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
The infection of virus such as respiratory syncytial virus is involved in pathogenesis of allergy during prenatal and postnatal infants, although the interaction between candidate genes and virus infection remains to be elucidated. We demonstrated hypomethylation of CpG islands produced by virus infection in IL4RA gene in splenic cells for postpartum infants from pregnant model mouse. Epidemiologic study showed the hypomethylation of CpG islands in in IL4RA gene in monocytes in cord blood of pregnant patients with asthma sensitized by house dust. These results suggest expression of IL4RA gene in just new born infants is produced by infection of RS virus.
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志賀町健康調査における高齢者のBMIと疾患との関係
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DOI: --
发表时间:
期刊:
影响因子: --
作者: [Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H, 北岡政美]
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慢性咳嗽患者における黄砂アレルギー症状への影響
黄沙过敏症状对慢性咳嗽患者的影响
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Usui C, Hatta K, Doi N, Nakanishi A, Nakamura H, Nishioka K, Arai H., 矢野栄二・竹内武昭, 東朋美,神林康弘,大倉徳幸,藤村政樹,西條清史,早川和一,小林史尚,道上義正,人見嘉哲,中村裕之]
通讯作者: 東朋美,神林康弘,大倉徳幸,藤村政樹,西條清史,早川和一,小林史尚,道上義正,人見嘉哲,中村裕之
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DOI: --
发表时间: 2012
期刊:
影响因子: --
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Increased systemic inflammatory interleukin-1β and interleukin-6 during agitation as predictors of Alzheimer disease
躁动期间全身炎症性白细胞介素 1β 和白细胞介素 6 增加作为阿尔茨海默病的预测因子
DOI: --
发表时间: 2012
期刊: Int J Geriatr Psychiatry
影响因子: --
作者: [Mizumura K, Murase S, Taguchi T, Honma T]
通讯作者: Honma T
44
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