Identification of genetic polymorphisms associated with onset of neuropathic pain and therapeutic efficacy

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Huge individual differences in vulnerability to neuropathic pain and in responsibility to its therapy hamper effective therapy for neuropathic pain. In the present study, we focused on bilateral sagittal split ramus osteotomy (BSSRO) which is a common orthognatic surgical procedure and causes peripheral nerve disturbances in some patients and not in the others. We conducted genome wide association study in 360 patients and found associations between genetic polymorphisms located in the ARID1B and ZPLD1 genes and hypoesthesia and between a genetic polymorphism in the METTL4 gene and dysesthesia.