Molecular and functional analysis of novel androgen receptor co-repressor in testicular cancer

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To test the hypothesis that reduction in AR transcriptional activity is associated with progression of testicular cancer, we analyze the function of ZNF288, novel AR co-repressor in testicular cancer cells. The result demonstrated that ZNF288 was able to form a co-repressor complex with HDAC2 and DNMT3B, and co-represses AR in TGCT model cell lines. Moreover, ZNF288 was shown to be an accelerator in in vivo testicular tumorigenesis assays in mice. In TCam-2, seminoma model cell line, up-regulation of AR transcriptional activity repressed cell growth.