Study on new regulatory mechanism for the function of myosin in neurons

FILIP通过与肌动蛋白结合蛋白之一的细丝蛋白A结合而在中枢神经系统的发育中发挥作用。本研究探讨了FILIP对神经元形态学的附加作用。我们观察到FILIP的表达在成人脑的有限区域中观察到。我们发现FILIP与一种非肌型肌球蛋白结合，改变了肌球蛋白的亚细胞分布，揭示了FILIP对兴奋性神经元形态的影响。我们的研究结果表明，FILIP通过结合肌球蛋白改变神经元的形态。这些结果表明，FILIP调节肌动球蛋白动力学，对神经元形态有一定的作用。

FILIP has a role in the development of central nervous system through the binding of filamin A that is one of the actin-binding proteins. We investigated the additional function of FILIP on the neuronal morphology in this study. We observed that the expression of FILIP was observed in the limited region of the adult brain. We found that FILIP bound to one of the non-muscle type myosin and altered the subcellular distribution of it. We disclosed that FILIP influenced on the morphology of the excitatory neurons. Our findings suggested that FILIP altered the morphology of neurons through the binding of the myosin. These results indicate that FILIP regulated actomyosin dynamics that have a role on the neuronal morphology.