Surface modification of cardiovascular metal stents

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We report on the surface modifications of metal substrates for stent, such as cobalt-chrome alloy and titanium alloy, for endothelialization at their surfaces by anodic oxidation treatment and femtosecond laser irradiation, respectively. We evaluated the surfaces using endothelial cells attachment test and platelet adhesion test in vitro. These results show their possibilities to be useful stent surfaces which promote attachments of endothelial cells for inhibiting restenosis and suppress adhesion of platelet inducing thrombogenesis.Next, we investigated the mechanism of interactions between electrostatic force of the material surfaces and cell behaviors using an atomic force microscopy, a quartz crystal microbalance with dissipation monitoring, and a fluorescence microscope. The conformational changes of the serum protein modulate its configuration when adsorbed to the material surfaces and the initial cell behavior of cells on the surface with pre-adsorbed the protein.