The mechanism of the blood vessel relaxation function improvement dependent endothelium after the exercise training

运动训练后血管舒张功能改善依赖内皮细胞的机制

• 批准号: 23500787
• 负责人: FURUKAWA Satoshi
• 金额: $ 3.16万
• 依托单位: Toyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500787/
• 关键词: 安静時収縮期血圧; 3-ニトロチロシン; 血管弾性要素; 血管弛緩機能; SOD; NOS; ニトロチロシン; 高血圧改善; 運動トレーニング; 血管運動; 血圧; ニトロ化タンパク質

The purpose of this study is to clarify mechanisms of the resting systolic blood pressure improvement by the exercise training in the spontaneous hypertensive rats (SHR), from the histologic side attention to the nitration protein of the organization and the biochemical side attention to the relaxation ability of the thoracic aorta. I let SHR perform 10-week voluntary exercise training, and examined the relaxation ability of the thoracic aorta and the amount of nitration protein of the organization. A tendency to decrease of the 3-nitrotyrosine contents was recognized in the P2 fractions, but it does not lead to a lead to a significant level, and it is thought that reexamination is necessary. As for the physical elasticity element of the thoracic aorta, a tendency to improve by exercise training was recognized, but needs the further examination such as thoracic aorta relaxation functions.

本研究的目的是从组织学侧面关注组织的硝化蛋白，从生化侧面关注胸主动脉的松弛能力，阐明运动训练改善自发性高血压大鼠(SHR)静息收缩压的机制。我让SHR进行了10周的自愿运动训练，并检测了胸主动脉的松弛能力和组织中的硝化蛋白含量。P2组分中3-硝基酪氨酸含量有下降趋势，但未达到显著水平，认为有必要复查。关于胸主动脉的物理弹性因素，运动训练有改善的趋势，但还需要进一步的检查，如胸主动脉的松弛功能。

项目成果

古川覚（健康スポーツ学科）｜東洋大学研究者情報データベース

古川悟（健康体育系）| 东洋大学研究员信息数据库