Effects of pulmonary rehabilitation on inflammatory response, oxidative stress, and nitrosative stress in COPD patients

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Comprehensive pulmonary rehabilitation (PR) program used in the current study significantly improved the exercise endurance capacity in COPD patients. And it also decreased the level of serum TBARS, the marker of oxidative stress. However, there was no significant change in any of respiratory function tests between pre- and post-rehabilitation. On the other hand, serum nitrotyrosine, the marker for nitrosative stress, did not alter after PR. Inflammatory cytokines (TNF-alfa,IL-1, IL-6, Leptin) did not alter after PR, too. Furthermore, in severe COPD patients, PR may have a risk to induce further oxidative stress.Taken together above, our findings suggest that PR to COPD patients improves the exercise performance, and it also reduces the oxidative stress. However, PR with heavier exercise intensity might induce more oxidative stress in COPD patients, especially severe COPD patients, seen as the increase of urinary 8-OH-dG.