11C-labeling reactions promoted by quaternary ammnonium fluorides and their application for PET studies

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In this study, tetrabutylammonium fluoride (TBAF) was found to be a suitable base for the 11C-methylation reaction of versatile active methylene compounds. The TBAF-promoted 11C-methylation was useful for one-pot synthesis of 11C-labeled aminoisobutyric acid (11C-AIB) and 11C-labeling of ibuprofen. A novel 11C-labeled 5-aminolevulinic acid analog 11C-MALA was also developed. We evaluated these tracers by small animal PET studies. We found that 11C-AIB was a promising tracer for diagnosis of radiation therapy and 11C-MALA-PET was useful for prediction of PDT or SDT of cancers.