Control of Formose Reaction Using Polymer Nanostructures

为了构建选择性生成特定糖类的福尔摩斯反应体系，研究了利用气溶胶OT （AOT）反胶束和含有硼酸残基的聚合物进行福尔摩斯反应。与AOT反胶束的福尔摩斯反应表现出相当高的选择性，两个碳原子的福尔摩斯反应优先形成，而三个或更多碳原子的糖不明显产生。与低分子量硼酸和含有硼酸残基的聚合物的福尔摩斯反应也表明，根据硼酸种类的不同，福尔摩斯有选择性地形成。此外，还合成了一些新的聚合物作为福尔摩斯反应的反应介质。

Aiming at construction of formose reaction systems which selectively yield specific saccharides, formose reaction using aerosol OT (AOT) reverse micelles and polymers possessing boronic acid residues have been investigated in detail. The formose reaction with AOT reverse micelles exhibit rather high selectivity, in which formoses of two carbon atoms were formed preferentially whereas sugars of three or more carbon atoms were not produced significantly. The formose reaction with a low molecular weight boronic acid and polymers possessing boronic acid residues also indicated selective formation of formoses, depending on the type of boronic acid species. Furthermore, some new polymers were synthesized as reaction media for formose reaction.