Development of the controllable parameter deriving method of hydrodynamic gene therapy equipment

本研究旨在建立一种安全、高效、可重复的大动物局部流体动力学基因治疗的新导入系统，为物理非病毒载体基因治疗的临床应用奠定基础。制作了基因治疗时肝脏形态变化的有限元模型，使用FEM系统进行了分析。其结果是，延长了大鼠肝脏在实验时的实际形态变化的FE模型。该结果基于肝脏中的应激状态的估计结果带来合适的流体压力。

This research aimed at safety establishment of the new introduction system for the efficient local hydrodynamic gene therapy with high reproducibility in large animals, aiming at clinical application of the gene therapy by a physical non-viral vector. FE model reproducing the liver modification at the time of gene therapy was created, and it analyzed using the FEM system. As a result, elongation of the rat liver at the time of an experiment with an actual form change of FE model. The results brings suitable fluid pressure based on the estimated result of a stress state in liver.