Giantin regulates the early secretory pathway by controlling communication among Golgi stacks

高尔京系带在高尔基体周围的COPI囊泡运输中起作用。在这里，我们通过RNAi显示，失去功能的高尔夫球系绳，Giantin改变了高尔基体池的长度。RNAi细胞的货物转运增加。此外，RNAi细胞的表面糖基化模式和高尔基体酶的定位也发生了变化。这些结果表明，高尔基体系绳对高尔基体的形成可能是必要的，并提供了COPI囊泡运输的准确性。

Golgin tethers function in COPI vesicle transport around the Golgi apparatus. Here we show by RNAi that the loss-of-function of a golgin tether, Giantin changed the length of Golgi cisternae. Cargo transport increased in the RNAi cells. Furthermore, surface glycosylation patterns and localization of Golgi enzymes were changed in the RNAi cells. These suggest that golgin tethers may be necessary for Golgi formation and give an accuracy of COPI vesicle transport.