Gene expression of transcription factors in the central nervous system of primates

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Aging brought about increase in expression of immunity-related genes and decrease in expression of mitochondria- and synaptic transmission-related genes in the neocortex and the hippocampus of macaque monkeys. Gene expressions suggest that enhancement of mitochondrial function and remyelination occur in the human brain and deterioration of mitochondrial function and demyelination occur in the macaque brain.In the macaque neocortex, neocortex-specific gene groups were expressed in addition to gene expressions in common with the hippocampus. There were no genes of transcription factor whose expression was in concordance with the process of myelination or demyelination. Estrogen and related substances may regulate gene expressions of transcription factors, whose expression was in concordance with the degree of myelination.