The expression of beta-oxidation adjustment key factor ACC2 elucidation which aimed at the metabolic syndrome new therapy

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We propose that Acetyl-CoA Carboxylase 2 (ACC2) is an attractive therapeutic target of metabolic syndrome, and we analyzed the mechanisms implied in the regulation of ACC2 gene expression to develop a brand-new therapeutic approach of metabolic syndrome. Prior to this study, we had found that hepatic ACC2 expression was repressed by cholic acid administration in mice. We had also found that murine ACC2 gene had two different transcription initiation sites with two different transcriptional regulatory regions. In this study, we analyzed the transcriptional regulatory regions by cloning. We also investigated the alterations of the expressions of the ACC2 mRNA subtypes under special conditions such as high-fat feeding, fasting, and refeeding. According to our result, the regulatory mechanisms participated in the expression of the 3-side ACC2 mRNA seemed to become an therapeutic target to improve hepatic energy homeostasis.