Study on cytoprotective effects of tocotorienol in a cellular Parkinson's disease model

在本研究中，我们研究了生育三烯醇(T3)在细胞和小鼠帕金森病(PD)模型中的细胞保护作用。在细胞PD模型中，所有的T3同系物都通过激活PI3K/Akt信号通路发挥细胞保护作用。我们还发现雌激素受体(ER)β是PI3K/Akt信号的上游中介，并在体外证明了T3与ERβ的直接结合。此外，我们还发现，T3治疗可以缓解PD模型小鼠的PD相关症状。我们的数据表明，在细胞和小鼠PD模型中，T3通过ERβ/PI3K/Akt信号通路发挥细胞保护作用。

In the present study, we investigated the cytoprptective effects of tocotrienol (T3) in cellular and murine Parkinson's disease (PD) models. All T3 homologues exerted cytoprptective effects via activation of PI3K/Akt signaling pathway in a cellular PD model. We also identified estrogen receptor (ER) beta as an upstream mediator of PI3K/Akt signaling and demonstrated the direct binding of T3 to ER beta in vitro. Furthermore, we revealed that T3 treatment relieved PD-related symptoms in PD model mice.Our data have demonstrated that T3 elicits the cytoprotective effects via ER beta/PI3K/Akt signaling pathway in cellular and murine PD models.