Clarified the active mechanisms of the multiple functions of mushrooms within the human body after consumption
Clarified the active mechanisms of the multiple functions of mushrooms within the human body after consumption
批准号:
23580234
负责人:
EGUCHI FUMIO
金额:
$3.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
已显示蘑菇担子果热水提取物抑制血小板聚集。血小板聚集是由血小板与PAF受体结合引起的。许多蘑菇的血小板聚集抑制作用不仅通过考克斯代谢促进TXA 2,还证实了PLA 2和细胞膜磷脂1-烷基磷脂酰胆碱再生领域的活性。此外,已显示抑制ADP的产生,ADP的产生源于从血管内皮细胞破裂到致密颗粒血小板产生的过程。由于蘑菇是广泛的血小板聚集抑制功能中的活性物质,因此现在已知经常食用蘑菇有助于通过刺激血管、中性粒细胞活化和平滑肌收缩来改善血管内皮疾病的症状,改善肾性高血压,并有助于与血小板聚集相关的其他功能。
英文摘要
It has been shown that mushroom basidiocarp hot water extract suppresses platelet aggregation. Platelet aggrgation is caused by platelets binding to PAF receptors. The platelet aggregation suppression effect of many mushrooms not only promotes TXA2 through COX metabolism, both PLA2 and activity in the domain of regeneration of 1-alkyl phosphatidycholine, a cell membrane phospholipid, have also been confirmed. Also, suppression of ADP's production, which stems from the process passing from breakdown of vascular endothelials to dense granule platelet production, has been shown. Because mushroom are an active material in a wide range of platelet aggregation suppressive functions, regularly eating mushrooms is now known to contribute to improving the symptoms of vascular endothelial diseases by stimulating the blood vessels, neutrophil activation, and smooth muscle contraction, improving renal hypertension, and aiding other functions related to platelet aggregation.
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DOI:
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发表时间:
2011
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2012
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期刊:
Mushroom Science and Biotechnology 19(1)
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共 20 条
Elucidation of the multifunctional expression of mushrooms based on inflammatory regenerative medicine and neuroscience
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批准号:20H03050
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.23万
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财政年份:2020
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负责人:EGUCHI FUMIO
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依托单位:
The development of cultivation technology of highly advanced functional mushroom for age-related diseases and the evaluation of its efficacy
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批准号:26450235
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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负责人:EGUCHI FUMIO
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依托单位:
海外基金