Clarified the active mechanisms of the multiple functions of mushrooms within the human body after consumption

阐明食用菌多种功能在人体内的激活机制

• 批准号: 23580234
• 负责人: EGUCHI FUMIO
• 金额: $ 3.16万
• 依托单位: Tokyo University of Agriculture (2012-2013)Takasaki University of Health and Welfare (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580234/
• 关键词: きのこ; 生活習慣病; 血小板凝集抑制; ケモカイン遺伝子発現抑制; 機能性食品; 子実体; 担子菌; 微生物; 脂質異常症; 高血圧症; ヒト試験; 生理活性物質; えのき氷; 疾患モデル動物; 多機能性; ケモカイン遺伝子発言抑制

It has been shown that mushroom basidiocarp hot water extract suppresses platelet aggregation. Platelet aggrgation is caused by platelets binding to PAF receptors. The platelet aggregation suppression effect of many mushrooms not only promotes TXA2 through COX metabolism, both PLA2 and activity in the domain of regeneration of 1-alkyl phosphatidycholine, a cell membrane phospholipid, have also been confirmed. Also, suppression of ADP's production, which stems from the process passing from breakdown of vascular endothelials to dense granule platelet production, has been shown. Because mushroom are an active material in a wide range of platelet aggregation suppressive functions, regularly eating mushrooms is now known to contribute to improving the symptoms of vascular endothelial diseases by stimulating the blood vessels, neutrophil activation, and smooth muscle contraction, improving renal hypertension, and aiding other functions related to platelet aggregation.

已显示蘑菇担子果热水提取物抑制血小板聚集。血小板聚集是由血小板与PAF受体结合引起的。许多蘑菇的血小板聚集抑制作用不仅通过考克斯代谢促进TXA 2，还证实了PLA 2和细胞膜磷脂1-烷基磷脂酰胆碱再生领域的活性。此外，已显示抑制ADP的产生，ADP的产生源于从血管内皮细胞破裂到致密颗粒血小板产生的过程。由于蘑菇是广泛的血小板聚集抑制功能中的活性物质，因此现在已知经常食用蘑菇有助于通过刺激血管、中性粒细胞活化和平滑肌收缩来改善血管内皮疾病的症状，改善肾性高血压，并有助于与血小板聚集相关的其他功能。

项目成果

ヒメマツタケCJ-01乾燥子実体抽出物のヒアルロニダーゼ阻害活性の検討

姬松茸CJ-01干燥子实体提取物透明质酸酶抑制活性的检测

• 发表时间: 2011
• 作者: 茂木園美;吉本博明;菊川忠裕;江口文陽
• 通讯作者: 江口文陽

アミノ酸添加培地におけるきのこの菌糸成長の評価

氨基酸补充培养基中蘑菇菌丝生长的评价

• 发表时间: 2011
• 作者: 西島純基;鷲見亮;森伸夫;江口文陽
• 通讯作者: 江口文陽

からだがよろこぶエノキ氷健康レシピ

健康的金针冰配方，让你的身体快乐

• 发表时间: 2012
• 作者: 木田マリ;宮澤紀子;吉本博明;江口文陽
• 通讯作者: 江口文陽

Consideration of Mushroom Functionality

蘑菇功能的考虑

• 发表时间: 2011
• 期刊: Mushroom Science and Biotechnology 19(1)
• 作者: Fumio EGUCHI;Noriko MIYAZAWA;Takahide MATSUDA
• 通讯作者: Takahide MATSUDA

ヒメマツタケ（CJ-01）乾燥子実体抽出物のヒアルロニダーゼ阻害活性の検討

姬松茸干燥子实体提取物（CJ-01）透明质酸酶抑制活性的检测

• 作者: 戸川英二;林徳子;江口文陽;戸川英二(分担執筆);Fumio Eguchi;江口文陽
• 通讯作者: 江口文陽