Characterization of a novel lipoprotein receptor (LRP12) in chicken liver –The basic knowledge for lipid metabolism -

鸡肝中新型脂蛋白受体（LRP12）的表征-脂质代谢的基础知识-

• 批准号: 23580385
• 负责人: KAN Sato
• 金额: $ 3.41万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580385/
• 关键词: ニワトリ; 肝臓; リポ蛋白; 脂質代謝; 鶏

In present study, the function of LDL receptor related protein 12 (LRP12), a novel lipoprotein receptor in chickens, was characterized, and it is possible to utilize as the improvement in efficiency of the egg and meat production in chickens. LRP12 gene expression was high in liver of laying hens. Chicken LRP12 is the molecule for the uptake of LDL into cells, and it is a master regulator of lipoprotein uptake in chicken liver. In addition, LRP12 is characterized that the gene expression and lipoprotein uptake were no changed by the intracellular cholesterol concentrations of cells, and it plays the important role for the lipid recycling of liver-blood lipid-liver in chickens.

本研究对鸡LDL受体相关蛋白12（LRP 12）的功能进行了研究，为提高鸡产蛋和产肉效率提供了可能。LRP 12基因在蛋鸡肝脏中表达量较高。鸡LRP 12是将LDL摄取到细胞中的分子，并且它是鸡肝脏中脂蛋白摄取的主要调节剂。此外，LRP 12的基因表达和脂蛋白摄取不受细胞内胆固醇浓度的影响，在鸡肝脏-血脂-肝脏的脂质循环中起重要作用。

项目成果

Administration of insulin to newly hatched chicks improves growth performance via impairment of MyoD gene expression and enhancement of cell proliferation in chicken myoblasts

• DOI: 10.1016/j.ygcen.2011.11.043
• 发表时间: 2012-02-01
• 期刊: GENERAL AND COMPARATIVE ENDOCRINOLOGY
• 影响因子: 2.7
• 作者: Sato, Kan;Aoki, Michiru;Kamada, Tosihiko
• 通讯作者: Kamada, Tosihiko

dministration of insulin to newly hatched chicks improves growth performance via impairment of MyoD gene expression and enhancement of cell proliferation in chicken myoblasts.

对新孵出的雏鸡施用胰岛素可通过损害 MyoD 基因表达并增强鸡成肌细胞的细胞增殖来改善生长性能。

• 发表时间: 2012
• 期刊: Gen Comp Endocrinol.
• 作者: Sato;K.;Aoki;M.;Kondo;R.;Matsushita;K.;Akiba;Y.;Kamada;T.
• 通讯作者: T.

Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors

• DOI: 10.1016/j.cbpa.2010.10.028
• 发表时间: 2011-02-01
• 期刊: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
• 影响因子: 2.3
• 作者: Sato, Kan;Kamada, Toshihiko
• 通讯作者: Kamada, Toshihiko