Cooperative and antagonistic interaction between progesterone and eicosanoid in the ovary

我们的调查结果如下。1)排卵前成熟卵泡对考克斯-2的诱导作用可能受到包括P4在内的类固醇代谢的干扰以及涉及GIVA PLA 2代谢产物的前馈/反馈机制的调节。2)颗粒层中的PGE合酶仍不明确。3)在自行车大鼠的自然退化CL中，自毒素被鉴定为通过GIVA PLA 2下游功能诱导并促成组织重塑的新因子。4)该蛋白在妊娠期CL中也被诱导，并被认为在CL调节中具有独特的作用。由于这一事实和Fas表达的性质，妊娠、假孕和周期性流产的CL之间存在根本差异。

Our findings are as follows. 1) COX-2 induction by the preovulatory mature follicles could be regulated by a crosstalk with the metabolism of steroid including P4 and by a feedforward/feedback mechanism involving GIVA PLA2 metabolites. 2) PGE synthase in the granulosa layers remains undefined. 3) In naturally regressing CL of cycling rats, autotoxin was identified to be a novel factor that was induced and contributed to tissue remodeling via function downstream of GIVA PLA2. 4) This protein was also induced in CL of pregnancy and supposed to have distinct roles in CL regulation. With this fact and the nature of Fas expression, there is a fundamental difference among CL of pregnancy, pseudopegnancy, and the cycling.