Fundamental research on the prevention and treatment of intractable immune disease using a new Th2 immune activator

新型Th2免疫激活剂防治免疫疑难疾病的基础研究

• 批准号: 23580405
• 负责人: MORIMOTO Masahiro
• 金额: $ 3.33万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580405/
• 关键词: 免疫学; 免疫; 再生医療; Th2; 消化管寄生蠕虫

To analyze the mechanism of action also to isolation, of Th2 immune activator derived from parasites,we investigated the method of measuring the immune activity of a spleen cell and intestinal epithelial cells culture system. Only after trypsinization, the agent increased the dominant production of IL-4 is a Th2 cytokine by spleen cell culture system. We have not seen this action in the intestinal epithelial cells. These results showed that a materials receives the processing of the gastrointestinal tract, then acting lymphatic system after absorption. This culture system is considered to be useful as an active measurement method for the isolation. We have been also investigate the effective extraction methods.

为了分析寄生虫源性Th2免疫激活剂的作用机制和分离，我们研究了脾细胞和肠上皮细胞培养系统免疫活性的测定方法。只有胰蛋白酶化后，该药物才能增加脾细胞培养系统中Th2细胞因子IL-4的显性产量。我们还没有在肠上皮细胞中看到这种作用。结果表明，a物质经胃肠道处理，经吸收后再作用于淋巴系统。该培养系统被认为是一种有效的隔离检测方法。我们还研究了有效的提取方法。

项目成果

宿主-寄生虫の免疫

宿主-寄生虫免疫

• 发表时间: 2013
• 作者: Goto T;Tomikawa J;Fukanuma T;Abe H;Takase K;Imamura T;Sanbo M;Tomita K;Hirabayashi M;Tsukamura H;Maeda KI;Uenoyama Y;森本將弘
• 通讯作者: 森本將弘