Reproductive roles of the adipsin/ASP pathway mediated by immunological and lipid methabolic effects

免疫学和脂质代谢效应介导的adipsin/ASP途径的生殖作用

• 批准号: 23580407
• 负责人: KEN TAKESHI Kusakabe
• 金额: $ 3.49万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580407/
• 关键词: 胎盤; 補体; 脂質; 免疫; マウス; 流産; 脂質代謝; 妊娠生理

The adipsin/ASP system has a crosstalk effect in the processes of complement activation and cellular lipid uptaken. Involvement of adipsin/ASP system was examined in the reproductive physiology and abortion onset. In the abortion placenta, triglyceride and the related factors were elevated, and lipid droplets were increased in the vascular wall. Administration of recombinant adipsin to pregnant mice elavated abortion rate and promoted histological degeneration of the placenta. Lipid metabolic factors and pregnancy-associated cytokines were changed follwoing the adipsin treatment. Adipsin was produced mainly in the mammaly gland during pregnancy periods. It was suggested that adipsin/ASP system basically regulate lipid metabolism during pregnancy and abnormal activation could disturb normal pregnancy by systemic variation of mataboloc factors and cytokines, and by local toxic effects on the placental formation.

adipsin/ASP系统在补体激活和细胞脂质摄取过程中具有串扰效应。研究了adipsin/ASP系统在生殖生理和流产发生中的作用。流产胎盘中甘油三酯及相关因子升高，血管壁脂滴增多。妊娠小鼠给予重组脂蛋白酶可提高流产率，促进胎盘组织学变性。脂蛋白酶治疗后，脂代谢因子和妊娠相关细胞因子发生变化。在妊娠期，脂肪酶主要在乳腺中产生。提示adipsin/ASP系统基本上调节妊娠期脂代谢，异常激活可通过影响mataboloc因子和细胞因子的系统性变化及对胎盘形成的局部毒性作用而干扰正常妊娠。

项目成果

ウサギ胎盤で見られた特徴的な血管構造

兔胎盘中发现的特征性血管结构

• 发表时间: 2012
• 作者: 日下部健;林一彦;國吉信恵;加納聖;木曾康郎
• 通讯作者: 木曾康郎

Vascular structure of the placenta in the rabbit placenta.

兔胎盘胎盘的血管结构。

• 发表时间: 2012
• 作者: 武下愛;鳥海早紀;吉田優司;近藤友宏;木曾康郎;岡田利也;日下部健;Ken Kusakabe
• 通讯作者: Ken Kusakabe

Expression and Localization of NO Synthase Isoenzymes (iNOS and eNOS) in Development of the Rabbit Placenta

NO 合酶同工酶（iNOS 和 eNOS）在兔胎盘发育中的表达和定位

• DOI: 10.1262/jrd.11-128t
• 发表时间: 2012
• 期刊: Journal of Reproduction and Development
• 影响因子: 1.8
• 作者: Takano K;Tanaka N;Kawabe K;Moriyama M;Nakamura Y.;Khan H
• 通讯作者: Khan H

CBA/J ×DBA/2自然流産モデルにおける補体第二経路の関与

CBA/J × DBA/2 自然流产模型中补体替代途径的参与

• 发表时间: 2012
• 作者: 武下愛;鳥海早紀;吉田優司;近藤友宏;木曾康郎;岡田利也;日下部健
• 通讯作者: 日下部健

ウサギ胎盤における血管構築

兔胎盘的血管结构

• 发表时间: 2011
• 作者: 宮地隆廣;蛯原有紗;杉元聡子;脇谷晶一;吉岡竜太;高畠大樹;日下部健
• 通讯作者: 日下部健