The effects of various heart failure medications on heart rate variability and renin-angiotensin aldosterone system in dogs with mitral regurgitation.

本研究的目的是评估各种治疗心力衰竭的药物对慢性瓣膜性心脏病犬的自主神经张力和肾素-血管紧张素-醛固酮系统（RAAS）的影响。采用实验性二尖瓣返流犬5只。交叉试验采用呋塞米、呋塞米与匹莫苯丹、呋塞米、匹莫苯丹与依那利联用、阿唑塞米与安慰剂。各组间心率变异性各项指标无显著差异。尿醛固酮肌酐比值因呋塞米而升高，然而，同时服用依那普利似乎并未抑制RAAS的激活。亚唑塞米对RAAS的影响最小。

The purpose of this study was to evaluate the effects of various medication used for heart failure on autonomic tone and renin-angiotensin aldosterone system (RAAS) in dogs with chronic valvular heart disease. Five dogs with experimentally induced mitral regurgitation were used. Furosemide, furosemide and pimobendan, combination of furosemide, pimobendan and enaralril, azosemide and placebo were administered in the cross-over design. Variables of heart rate variability were not significantly different among groups. Urine aldosterone creatinine ratio was increased due to furosemide, however, concurrent administration of enalapril did not seem to suppress RAAS activation. Azosemide appeared minimally influence to RAAS.