Synthesis of inner-core oligosaccharides of LPS and its protein conjugates for a definition of the epitope recognized by human antibodies

在本研究中，我们先后实现了9种低聚糖的合成，它们是由致病菌革兰氏阴性菌产生的脂多糖/脂低聚糖的部分核心低聚糖。合成的寡糖被生物素标记，并与人血清白蛋白偶联。这些结合物将用于确定人类抗体识别的表位和开发针对致病性革兰氏阴性细菌感染的碳水化合物疫苗。

In this research, we successively achieved the synthesis of 9 type oligosaccharides, which are partial inner-core oligosaccarides of lipopolysaccharide/lipooligosaccharide produced by pathogenic gram-negative bacteria. And synthesized oligosaccharides were labeled with biotin and also conjugated to human serum albumin. These conjugates will be utilized for the definition of the epitope recognized by human antibody and the development of carbohydrate vaccine against pathogenic gram-negative bacterial infection.