Lysophosphatidic acid production by novel membrane-bound lysophospholipase D and protection of oral mucosa

溶血磷脂酸（Lysophosphatidic acid， LPA）是近年来备受关注的溶血磷脂介质家族成员，它通过激活6种特异性受体发挥多种生理作用。本研究发现健康人龈沟液（GCF）中LPA浓度比人混合唾液高10倍以上，而牙周炎患者龈沟液中LPA含量极低。发现后者是由于牙周炎患者GCF中lpa降解活性高得多。这些结果强烈表明，牙槽骨周围LPA的局部耗竭会导致骨吸收改变，从而导致牙周炎的恶化，因为已知LPA参与骨重塑。

Lysophosphatidic acid (LPA) is a member of lysophopsholipid mediator family that has recently attracted much attention, and exert diverse physiological effects through the activation of six its specific receptors.In the present study, the concentration of LPA in human gingival crevicular fluid (GCF) from healthy volunteers was found to be more than ten times higher human than thatin human mixed saliva, but the LPA levelin GCF from patients with periodontitis was found to be very low by liquid chromatography-tandem mass spectrometry. The latter was found to be due to much high er activity of LPA-degrading in GCF from the periodontitis patients. These results strongly indicate that local depletion of LPA around the alveolar bones results in the altered bone absorption leading to the aggravation of periodontits, because LPA is known to be involved in the bone remodeling.