Analysis of neuroprotective effect of pigment epithelium derived factor

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Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (SERPIN) gene family. PEDF is detected in a broad range of human tissues, including almost all brain areas, and has been shown to have strong neuroprotective properties for various types of neurons including cerebellar granule neurons, hippocampal neurons, striatal neurons, retinal neurons and spinal cord motor neurons.These observations raise thepossibility that application of PEDF may be helpful in designing new therapeutic strategies forneurodegenerative diseases. In this study. we tested neuroprptective effect of PEDF in vivo and in vitro.