Control of multiwall carbon nanotube-induced inflammatory responses by cellular cholesterol

由于碳纳米管具有类似石棉的形状和大小，人们对其对环境和健康的不利影响感到担忧。研究表明它们与小鼠的炎症、间皮瘤和动脉粥样硬化进展有关。在这项研究中，我们研究了多壁碳纳米管（MWCNT）诱导炎症细胞因子il -1 β产生受胆固醇调节的机制。我们发现MWCNTs被纳入THP-1巨噬细胞，并通过NLRP3炎性体激活诱导il -1 β成熟。这种作用可通过MWCNTs与肺表面活性剂样磷脂的分散而增强。各种他汀类药物通过减少MWCNTs的细胞摄取来抑制MWCNTs诱导的il -1 β释放。

Because cnanotubes have asbestos-like shape and size, concerns about their adverse effect on environment and health have been raised. Studies have shown their association with inflammation, mesothelioma, and atherosclerosis progression in mice. In this study, we investigated the mechanism by which multiwall carbon nanotubes (MWCNT)-induced production of an inflammatory cytokine IL-1beta is regulated by cholesterol. We found that MWCNTs were incorporated into THP-1 macrophages and induced IL-1beta maturation via NLRP3 inflammasome activation. This effect is enhanced by dispersion of MWCNTs with lung-surfactant-like phospholipids. Various statins repressed MWCNT-induced IL-1beta release by reducing cellular uptake of MWCNTs.