Degradation of cation channel and the dysfunction
Degradation of cation channel and the dysfunction
批准号:
23590312
负责人:
MURAKI Katsuhiko
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
In this research project, we have found that TRPA1 channel, a subfamily of TRP cation channel, is substantially induced by inflammatory stimuli in channel-expression and channel-function levels; a transcriptiona factor, which is activated in hypoxia, is involved in the induction and TRPA1 gene promoter has a specific binding site of the factor. Because TRPA1 channel is involved in nociception, the present finding may contribute to developement of novel drugs for inflammatory nociception.
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低酸素誘導因子HIF1αによるTRPA1チャネル発現制御機構
缺氧诱导因子HIF1α对TRPA1通道表达的调节
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[波多野紀行, 伊藤友香, 鈴木裕可, 村木由起子, 林秀敏, 小野嵜菊夫, Wood Ian,Beech David, 村木克彦]
通讯作者:
村木克彦
ヒト脳毛細血管内皮細胞においてhistamineにより惹起されるCl^-電流におけるanoctaminチャネルの寄与の検討
检查人脑毛细血管内皮细胞中阿辛胺通道对组胺诱导的 Cl^-电流的贡献
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[波多野紀行, 鈴木裕可, 村木由起子, 大矢進, 村木克彦]
通讯作者:
村木克彦
Transcriptional regulation of transient receptor potential ankyrin 1 channel gene expression by hypoxia inducible factor-1α.
缺氧诱导因子-1α对瞬时受体电位锚蛋白1通道基因表达的转录调节。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Noriyuki Hatano, Yuka Itoh, Hiroka Suzuki, Yukiko Muraki, Hidetoshi Hayashi, Kikuo Onozaki, Ian Wood, David Beech, Katsuhiko Muraki, 吉田善紀, 波多野紀行, 吉田善紀, Noriyuki Hatano, Noriyuki Hatano]
通讯作者:
Noriyuki Hatano
TRPC5 channel sensitivities to antioxidants and hydroxylated stilbens.
TRPC5 通道对抗氧化剂和羟基化二苯乙烯的敏感性。
DOI:
--
发表时间:
2011
期刊:
J.Biol.Chem. 286
影响因子:
--
作者:
[J Naylor, E Shawaf, P Manna, L McKeown, P Manna, K. Porter, D O'Regan, K Muraki, D Beech]
通讯作者:
D Beech
NADPHオキシダーゼ阻害剤はTRPA1チャネルを活性化する
NADPH 氧化酶抑制剂激活 TRPA1 通道
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[鈴木裕可, 波多野紀行, 村木由起子, 伊藤友香, 林秀敏, 小野嵜菊夫, 村木克彦]
通讯作者:
村木克彦
共 23 条
Regulation of expression of vascular cation channels by transcriptional and epigenetical modulation
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批准号:20590263
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2008
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负责人:MURAKI Katsuhiko
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依托单位:
Regulation of differentiation and reproduction of vascular organs by Edg receptor expression
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批准号:15590064
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:MURAKI Katsuhiko
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依托单位:
Relationship between lipid mediator receptors and lipid-induced impairment of human endothelial cells
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批准号:13672293
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2001
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负责人:MURAKI Katsuhiko
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依托单位: