Effects of restrained water immersion stress on the metabolism of histamine in the gastric mucosa.

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Restrained water immersion stress of 30 min (WRS) in mice and rats caused mild ulcer in the gastric mucosa. Histamine content in the gastric mucosa increased 1.6 and 1.3 times, respectively. Anti-histamine N-methyltransferase (HMT) antibody detected a band in rat kidney, but not in gastric mucosa. Quantitative PCR detected HMT mRNA in gastric mucosa, but the expression level did not change by WRS. Anti-histidine decarboxylase antibody detected a single band in the rat gastric mucosa but the content did not change by WRS. Anti-diamine oxidase antibody failed to detect expression in the gastric mucosa. The phosphorylation level of MAP kinases (ERK1/2, SAPK/KNK, p38) did not change by WRS.