Molecular mechanisms for the pathogenesis of cancer cachexia that is observed in a conditionally K-raG12V-expressed tumor model animal

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We have identified an oncogenic K-rasG12V conditional tumor mouse model as both a pleomorphic rhabdomyosarcoma and a cancer cachexia model when K-rasG12V is specifically expressed in skeletal musculature cells. We have elucidated crucial roles of Interleukin-6 (IL-6), one of major inflammatory cytokines, and brain natriuretic peptide (BNP) and parathyroid hormone-related protein in the pathogenesis of cancer cachexia through phenotypic characterization of whole bodies that are inoculated with tumor-derived cell lines and analysis of induced tumors.Furthermore, We have suggested forkhead box N1, one of the forkhead family or "winged-helix" transcription factors, as one of cachexia-sensitive factors for the tumor bearing individual.