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Functional alalysis of clock genes in highly aggressive pancreato-biliary cancer

Functional alalysis of clock genes in highly aggressive pancreato-biliary cancer
高侵袭性胰胆管癌时钟基因的功能分析
批准号:
23590386
负责人:
KIJIMA Hiroshi
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

项目摘要

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中文摘要
翻译
胰胆道癌是人类最具侵袭性的恶性肿瘤之一。其侵袭性表型被认为与通过上皮-间充质转化(EMT)的侵袭性肿瘤生长以及通过肿瘤血管生成的血管渗透有关。Clock基因不仅调节人体的昼夜节律(生物钟),而且还调节肿瘤细胞的生长、EMT和胰胆管癌细胞的血管生成。
英文摘要
Pancreato-biliary cancer is one of the most aggressive malignancies of human. Its aggressive phenotypes are thought to be associated with invasive tumor growth via epithelial-mesenchymal transition (EMT), as well as vascular permeation via tumor angiogenesis. Clock genes regulate not only circadian rhythm (biological clock) of human bodies, but also tumor cell growth, EMT, and tumor angiogenesis of the pancreato-biliary cancer.
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会议论文
Histopathological Characteristics of Laterally Spreading Tumor(LST) Type Early Colorectal Cancer
横向扩散肿瘤(LST)型早期结直肠癌的组织病理学特征
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [Kaori Takasugi, S. Morohashi, Toshihiro Haga, Takahito Toba, H. Seino, Yunyan Wu, Takahiro Suzuki, N. Hanabata, Y. Sasaki, S. Fukuda, H. Kijima]
通讯作者: H. Kijima
DOI: 10.3892/or.2012.1971
发表时间: 2012-11
期刊: Oncology reports
影响因子: 4.2
作者: [Okada K, Kijima H, Imaizumi T, Hirabayashi K, Matsuyama M, Yazawa N, Dowaki S, Tobita K, Ohtani Y, Tanaka M, Inokuchi S, Makuuchi H]
通讯作者: Makuuchi H
Claudin-1 is associated with invasive growth of human pancreatic cancer
Claudin-1 与人类胰腺癌的侵袭性生长相关
DOI: --
发表时间: 2012
期刊: Hirosaki Med J
影响因子: --
作者: [Kondo J, Sato F, Wu Y, Seino H, Morohashi S, Kijima H]
通讯作者: Kijima H
Basic helix-loop-helix transcription factor DEC2 negatively regulates pro-apoptotic factor Bim in cisplatin-treated human oral cancer cells
顺铂处理的人口腔癌细胞中碱性螺旋-环-螺旋转录因子DEC2负向调节促凋亡因子Bim
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Wu Y, Seino H, M orohashi S, Yoshizawa T, Kato Y, Kijima H]
通讯作者: Kijima H
46
    Pathophysiological modulation of high-grade malignant potentials of pancreato-biliary cancer, and its clinical application
    • 批准号:
      17H04057
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.74万
    • 财政年份:
      2017
    • 负责人:
      KIJIMA Hiroshi
    • 依托单位:
    Clock genes regulates tumor growth and tumor angiogenesis of human pancreato-biliary cancer.
    • 批准号:
      20590334
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.58万
    • 财政年份:
      2008
    • 负责人:
      KIJIMA Hiroshi
    • 依托单位:
    Pathology and molecular targeting of human pancreatic cancer
    • 批准号:
      17590291
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      2005
    • 负责人:
      KIJIMA Hiroshi
    • 依托单位:
    Anti-oncogene hammerhead ribozymes (RNA enzymes) specifically inhibit oncogens in a mice model system.
    • 批准号:
      09670239
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      1997
    • 负责人:
      KIJIMA Hiroshi
    • 依托单位:
    海外基金