Functional alalysis of clock genes in highly aggressive pancreato-biliary cancer

高侵袭性胰胆管癌时钟基因的功能分析

• 批准号: 23590386
• 负责人: KIJIMA Hiroshi
• 金额: $ 3.24万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590386/
• 关键词: 癌; 膵臓; 時計遺伝子; 血管新生; 遺伝子制御; 胆道; 抗アポトーシス

Pancreato-biliary cancer is one of the most aggressive malignancies of human. Its aggressive phenotypes are thought to be associated with invasive tumor growth via epithelial-mesenchymal transition (EMT), as well as vascular permeation via tumor angiogenesis. Clock genes regulate not only circadian rhythm (biological clock) of human bodies, but also tumor cell growth, EMT, and tumor angiogenesis of the pancreato-biliary cancer.

胰胆管癌是恶性肿瘤之一。 其侵袭性表型被认为与通过上皮-间质转化（EMT）的侵袭性肿瘤生长以及通过肿瘤血管生成的血管渗透相关。 生物钟基因不仅调节人体的昼夜节律（生物钟），还调节胰胆管癌的肿瘤细胞生长、EMT和肿瘤血管生成。

项目成果

Basic helix-loop-helix transcription factor DEC2 negatively regulates pro-apoptotic factor Bim in cisplatin-treated human oral cancer cells

顺铂处理的人口腔癌细胞中碱性螺旋-环-螺旋转录因子DEC2负向调节促凋亡因子Bim

• 发表时间: 2012
• 作者: Wu Y;Seino H;M orohashi S;Yoshizawa T;Kato Y;Kijima H
• 通讯作者: Kijima H

Claudin-1 is associated with invasive growth of human pancreatic cancer

Claudin-1 与人类胰腺癌的侵袭性生长相关

• 发表时间: 2012
• 期刊: Hirosaki Med J
• 作者: Kondo J;Sato F;Wu Y;Seino H;Morohashi S;Kijima H
• 通讯作者: Kijima H

Clinical significance of wall invasion pattern of subserosa-invasive gallbladder carcinoma.

• DOI: 10.3892/or.2012.1971
• 发表时间: 2012-11
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Okada K;Kijima H;Imaizumi T;Hirabayashi K;Matsuyama M;Yazawa N;Dowaki S;Tobita K;Ohtani Y;Tanaka M;Inokuchi S;Makuuchi H
• 通讯作者: Makuuchi H

Histopathological Characteristics of Laterally Spreading Tumor（LST） Type Early Colorectal Cancer

横向扩散肿瘤（LST）型早期结直肠癌的组织病理学特征

• 发表时间: 2014
• 作者: Kaori Takasugi;S. Morohashi;Toshihiro Haga;Takahito Toba;H. Seino;Yunyan Wu;Takahiro Suzuki;N. Hanabata;Y. Sasaki;S. Fukuda;H. Kijima
• 通讯作者: H. Kijima

PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells

• DOI: 10.1016/j.ejca.2011.02.025
• 发表时间: 2011-07-01
• 期刊: EUROPEAN JOURNAL OF CANCER
• 影响因子: 8.4
• 作者: Sato, Fuyuki;Wu, Yunyan;Kijima, Hiroshi
• 通讯作者: Kijima, Hiroshi