Proteomic analysis of arterial aging and medial degenerative diseases (aortic dissection, cerebral aneurysm and cerebral arterial dissection)

与年龄相关的动脉中层变化（动脉老化）导致老年人心力衰竭和慢性肾脏疾病。主动脉夹层可能是由于主动脉中膜的某些不明异常引起的。本研究旨在应用蛋白质组学方法分析动脉内膜组成蛋白在动脉老化和主动脉夹层中的变化。在主动脉夹层病例中，平滑肌收缩蛋白增加和减少，应激反应蛋白增加，细胞外基质蛋白减少。动脉增龄与平滑肌肌动蛋白减少、应激反应蛋白增加和细胞外糖胺聚糖蛋白增加有关。我们成功地鉴定了动脉老化和主动脉夹层中动脉中层组成蛋白的特异性变化。

The aging-related arterial medial change (arterial aging) causes heart failure and chronic kidney disease in the elderly. Aortic dissection may arise from some unidentified anomaly of the aortic media. The purpose of this study is to analyze the changes of arterial medial constitutive proteins in arterial aging and aortic dissection using the comprehensive proteome analysis. In the cases of aortic dissection, there were increase and decrease of smooth muscle contraction proteins, increase of stress response proteins, and decrease of extracellular matrix proteins. Arterial aging was associated with decrease of smooth muscle actin, increase of stress response proteins, and increase of proteins of extracellular glycosaminoglycans. We successfully identified the specific changes of arterial medial constitutive proteins seen in arterial aging and aortic dissection.