The analysis of the new inhibitory factor for cytomegalovirus in ES/iPS cells

多能干细胞（iPS/ES细胞）表现出对巨细胞病毒的抗性。我们利用Yamanka因子从人成纤维细胞中培养iPS细胞。iPS对CMV感染表现出显著的抗性。这与以前的报告（Plos one: 10.1371/journal.pone.0017492）是兼容的。我们试图研究这种抑制现象的新因素。新的因素还没有发现。相反，我们试图找到CMV在脑中的已知受体（CD29）分布。内皮细胞、周细胞、脑膜、胆鞘丛和NSPC均表达较高水平的CD29。高水平表达CD29的细胞与MCMV感染细胞的共表达高度相关。在大脑里。我们得出结论，巨细胞病毒感染主要是在急性感染期由高水平表达CD29的细胞引发感染。

Pluripotent stem cell (iPS/ES cells) showed resistance to CMV. We established iPS cells from human fibroblast using Yamanka factors. iPS showed remarkable resistance to CMV infection. This is the compatible with previous report (Plos one: 10.1371/journal.pone.0017492). We tried to investigate the new factor for this inhibitory phenomenon.The new factor has not been found yet. Instead, we tried to find known receptor (CD29) distribution for CMV in brain. Endothelial cells, pericytes, meninges, choloid plexus and NSPC all express higher level of CD29 than other area of the brain. Co-expression of higher level of CD29 expressing cells and MCMV infected cells were highly correlated. In the brain. We concluded that cytomegalovirus infection primarily initiates infection from high-level CD29 expressing cells in acute infection phase.