Identification of HOX gene which suppresses hepatic metastasis of colon cancer

抑制结肠癌肝转移的HOX基因的鉴定

• 批准号: 23590451
• 负责人: HAMADA Jun-ichi
• 金额: $ 3.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590451/
• 关键词: 転移; HOX; 浸潤; 大腸癌; 肝転移; ホメオボックス遺伝子; がん転移; 大腸がん; 位置情報

In this study, we examined the roles of HOXD8 in three steps of hepatic metastasis of human colon cancer to demonstrate anti-metastatic function of HOXD8. We found the following: the cells highly invasive of subendothelial basement membrane showed higher expressions of HOXD8 than those weakly invasive; there was no correlation between adhesiveness of the cells to hepatic sinusoidal endothelial cells and the expression levels of HOXD8; the cells growing in the liver of nude mice expressed HOXD8 at higher levels than those growing in the cecum. These results suggested that HOXD8 functioned as a metastasis-enhancing or –suppressive gene depending on the step where the cells were during hepatic metastasis.

在这项研究中，我们在人类结肠癌的肝脏转移的三个步骤中检查了HOXD8的作用，以证明HOXD8的抗转移功能。我们发现了以下内容：高度侵入性下皮地下膜的细胞显示出HOXD8的表达比弱侵入性的细胞更高。细胞与肝曲正弦内皮细胞的粘附性与HOXD8的表达水平之间没有相关性。裸鼠肝脏中生长的细胞比在盲肠中生长的细胞在更高的水平上表达了HOXD8。这些结果表明，HOXD8起着转移增强的作用或 - 抑制基因，具体取决于细胞在肝转移期间的细胞的步骤。

项目成果

Differential Expressions of Matrix Metalloproteinases, A Disintegrin and Metalloproteinases, and a Disintegrin and Metalloproteinases with Thrombospondin Motifs and their Endogenous Inhibitors Among Histologic Subtypes of Lung Cancers

• DOI: 10.2174/187152012802650156
• 发表时间: 2012-09-01
• 期刊: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
• 影响因子: 2.8
• 作者: Hida, Yasuhiro;Hamada, Jun-ichi
• 通讯作者: Hamada, Jun-ichi

ヒト悪性胸膜中皮腫細胞の低酸素培養状態における細胞運動・浸潤能の増強

低氧培养条件下人恶性胸膜间皮瘤细胞的细胞运动和侵袭能力增强

• 发表时间: 2012
• 作者: 斎藤憲;中西速夫;近藤英作;ゴウダルジホウマヌ・飯笹久・古橋昌子・中澤誠多朗・中根梨恵・柳原五吉・久保貴紀・浜田淳一
• 通讯作者: ゴウダルジホウマヌ・飯笹久・古橋昌子・中澤誠多朗・中根梨恵・柳原五吉・久保貴紀・浜田淳一

Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma

• DOI: 10.2220/biomedres.34.13
• 发表时间: 2013-02-01
• 期刊: BIOMEDICAL RESEARCH-TOKYO
• 影响因子: 1.2
• 作者: Goudarzi, Houman;Hida, Yasuhiro;Hamada, Jun-ichi
• 通讯作者: Hamada, Jun-ichi

Enhacement of cell motility and invasion of malignant pleural mesothelioma cells through HIF1alpha-MUC1 pathway

通过 HIF1α-MUC1 通路增强恶性胸膜间皮瘤细胞的细胞运动和侵袭

• 发表时间: 2012
• 作者: Houman Goudarzi;Hisashi Iizasa;Masako Furuhashi;Rie Nakane;Seitaro Nakazawa;Yasuhiro Hida;Kazuyoshi Yanagihara;Takanori Kubo and Jun-ichi Hamada
• 通讯作者: Takanori Kubo and Jun-ichi Hamada

Oral Cancer InTech

口腔癌 InTech

• 发表时间: 2012
• 作者: Hassan NMM;Tada M;Hamada J;Shindoh M;Kashiwazaki H;Yamazaki Y;Ashikaga Y;Moriuchi T;Inoue N and Sasaki A.
• 通讯作者: Inoue N and Sasaki A.