Identification of HOX gene which suppresses hepatic metastasis of colon cancer

抑制结肠癌肝转移的HOX基因的鉴定

• 批准号: 23590451
• 负责人: HAMADA Jun-ichi
• 金额: $ 3.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590451/
• 关键词: 転移; HOX; 浸潤; 大腸癌; 肝転移; ホメオボックス遺伝子; がん転移; 大腸がん; 位置情報

In this study, we examined the roles of HOXD8 in three steps of hepatic metastasis of human colon cancer to demonstrate anti-metastatic function of HOXD8. We found the following: the cells highly invasive of subendothelial basement membrane showed higher expressions of HOXD8 than those weakly invasive; there was no correlation between adhesiveness of the cells to hepatic sinusoidal endothelial cells and the expression levels of HOXD8; the cells growing in the liver of nude mice expressed HOXD8 at higher levels than those growing in the cecum. These results suggested that HOXD8 functioned as a metastasis-enhancing or –suppressive gene depending on the step where the cells were during hepatic metastasis.

在这项研究中，我们研究了HOXD 8在人类结肠癌肝转移的三个步骤中的作用，以证明HOXD 8的抗转移功能。 我们发现以下内容：内皮下基底膜浸润性强的细胞HOXD 8表达高于浸润性弱的细胞，细胞与肝窦内皮细胞的浸润程度与HOXD 8表达水平无相关性，裸鼠肝脏中生长的细胞HOXD 8表达水平高于盲肠中生长的细胞。 这些结果表明，HOXD 8作为一个转移增强或抑制基因的功能取决于细胞在肝转移过程中的步骤。

项目成果

Enhacement of cell motility and invasion of malignant pleural mesothelioma cells through HIF1alpha-MUC1 pathway

通过 HIF1α-MUC1 通路增强恶性胸膜间皮瘤细胞的细胞运动和侵袭

• 发表时间: 2012
• 作者: Houman Goudarzi;Hisashi Iizasa;Masako Furuhashi;Rie Nakane;Seitaro Nakazawa;Yasuhiro Hida;Kazuyoshi Yanagihara;Takanori Kubo and Jun-ichi Hamada
• 通讯作者: Takanori Kubo and Jun-ichi Hamada

Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma

• DOI: 10.2220/biomedres.34.13
• 发表时间: 2013-02-01
• 期刊: BIOMEDICAL RESEARCH-TOKYO
• 影响因子: 1.2
• 作者: Goudarzi, Houman;Hida, Yasuhiro;Hamada, Jun-ichi
• 通讯作者: Hamada, Jun-ichi

Regulatory mechanisms of SOX2 expression in human breast carcinoma cells

人乳腺癌细胞SOX2表达的调控机制

• 发表时间: 2012
• 作者: Shanshan Liang;Hisashi Iizasa;Masako Furuhashi;Seitaro Nakazawa;Rie Nakane and Jun-ichi Hamada
• 通讯作者: Rie Nakane and Jun-ichi Hamada

Oral Cancer InTech

口腔癌 InTech

• 发表时间: 2012
• 作者: Hassan NMM;Tada M;Hamada J;Shindoh M;Kashiwazaki H;Yamazaki Y;Ashikaga Y;Moriuchi T;Inoue N and Sasaki A.
• 通讯作者: Inoue N and Sasaki A.

ホメオボックス遺伝子HOXD8のヒト大腸癌の肝転移における役割について

同源盒基因HOXD8在人结直肠癌肝转移中的作用

• 发表时间: 2013
• 作者: Fujimaki M;Fukumura Y;Saito T;et al.;古橋昌子・浜田淳一
• 通讯作者: 古橋昌子・浜田淳一