Elucidation of the crucial role of Adrenomedullin-Ramp2,Ramp3 system in mouse models of inflammation

受体活性修饰蛋白(RAMP)2或3是肾上腺髓质素(AM)受体的组成部分。斜坡被认为是独特的AM功能的重要因素。本研究利用RAMP2条件性KO和RAMP3KO小鼠，研究了肾上腺髓质素-RAMP2、RAMP3系统在腹膜和结肠炎症状态中的作用，包括血管、心脏和肾脏的病理状态。研究表明，Ramp2参与支持器官功能，而Ramp3在炎症反应中起关键作用。这些结果表明，这些斜坡相互独立地发挥作用，但它们为维持器官内环境平衡做出了协调反应。

Receptor-activity-modifying protein (Ramp) 2 or 3 is a part of the Adrenomedullin (AM) receptor. The Ramps became suggested to be important for unique AM function. In this study, the role of Adrenomedullin-Ramp2, Ramp3 system were investigated in inflammatory conditions of the peritoneum and the colon, including pathological conditions of several organs (blood vessel, heart and kidney) by using Ramp2 conditional KO and Ramp3KO mice. It has revealed that Ramp2 is involved in supporting organ function, and Ramp3 plays a crucial role in inflammatory response. These results obtained suggest that the Ramps function independently of each other, however they make a coordinated response for maintaining organ homeostasis.