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Aberrant differentiation of dendritic cells in malaria infection associated with decreased expression of IRF4/IRF8

Aberrant differentiation of dendritic cells in malaria infection associated with decreased expression of IRF4/IRF8
疟疾感染中树突状细胞的异常分化与 IRF4/IRF8 表达降低相关
批准号:
23590492
负责人:
ICHINO Motohide
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
It has been reported that malaria parasite infection suppresses host immune system by interfering with the maturation of dendritic cells (DCs) playing a pivotal role in immune responses. However the molecular mechanisms are not well understood. The present study shows that malaria parasite-infected erythrocytes can interact with host bone-marrow cells and cause aberrant differentiation of DCs by suppressing the transcriptional expression of transcription factors IRF4 and IRF8, by using a mouse model of malaria parasite infection.
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Introduce My Article “Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.”
介绍我的文章“IRF8-KLF4 转录因子级联在小鼠单核细胞分化中的重要作用”。
DOI: --
发表时间: 2013
期刊: 臨床血液
影响因子: --
作者: [Watanabe T, Hotta C, Koizumi S, Miyashita K, Nakabayashi J, Kurotaki D, Sato GR, Yamamoto M, Nakazawa M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Ikezawa Z, Aihara M, Ishigatsubo Y, Tamura T., 黒滝大翼,田村智彦]
通讯作者: 黒滝大翼,田村智彦
DOI: 10.1371/journal.pone.0025812
发表时间: 2011
期刊: PloS one
影响因子: 3.7
作者: [Yamamoto M, Kato T, Hotta C, Nishiyama A, Kurotaki D, Yoshinari M, Takami M, Ichino M, Nakazawa M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T]
通讯作者: Tamura T
Regulation of the development of monocyte subsets by interferon regulatory factor 8
干扰素调节因子 8 对单核细胞亚群发育的调节
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kurotaki D, Ichino M, Nishiyama A, Sato G, Yamamoto M, Ozato K, Tamura T]
通讯作者: Tamura T
Genome-wide analyses revealed the IRF8-KLF4 transcription factor cascade during monocytedifferentiation
全基因组分析揭示了单核细胞分化过程中 IRF8-KLF4 转录因子级联反应
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kurotaki D., et al.]
通讯作者: et al.
21
    Inhibition of dendritic cell development via the suppression of transcription factor IRF8 by malaria
    • 批准号:
      16K08764
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2016
    • 负责人:
      ICHINO Motohide
    • 依托单位:
    Curative effects of CpG DNA administration on scleroderma-like syndrome of Tsk/+mice
    • 批准号:
      13670466
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $0.96万
    • 财政年份:
      2001
    • 负责人:
      ICHINO Motohide
    • 依托单位:
    海外基金