Regulation of virulence gene expressions in high-virulent lineages of enterohemorrhagic E. coli

肠出血性大肠杆菌高毒力谱系毒力基因表达的调控

• 批准号: 23590528
• 负责人: IYODA SUNAO
• 金额: $ 3.41万
• 依托单位: National Institute of Infectious Diseases
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590528/
• 关键词: 腸管出血性大腸菌; LEE; 発現制御

We examined the distribution of clades and stx subtypes of enterohemorrhagic E. coli (EHEC) isolates, which were collected in Japan to assess their public health significance. Using epidemiologically unrelated EHEC O157:H7 isolates from more than 250 hemolytic uremic syndrome (HUS) patients and 350 asymptomatic carriers (designated as ACs hereafter), all of which exhibited distinct pulsed-field gel electrophoresis patterns, we observed that diffrent clades with particular stx subtypes were associated with HUS and ACs, respectively.

我们检查了在日本收集的肠出血性大肠杆菌（EHEC）分支和六种亚型的分布，以评估其公共卫生意义。从250多例溶血性尿毒症（HUS）患者和350例无症状携带者（以下称为ACs）中分离出的EHEC O157:H7株流行病学上无关，均表现出不同的脉冲场凝胶电泳模式，我们观察到具有特定stx亚型的不同进化支分别与溶血性尿毒症和ACs相关。

项目成果

腸管出血性大腸菌感染症の現況と保有する接着因子について

肠出血性大肠杆菌感染现状及粘附因素

• 发表时间: 2012
• 作者: 林直樹;皆川周;後藤直正;神谷 茂;伊豫田淳，石原朋子，寺嶋淳，大西真，EHECワーキンググループ
• 通讯作者: 伊豫田淳，石原朋子，寺嶋淳，大西真，EHECワーキンググループ

Variation in Stress Resistance Patterns among stx Genotypes and Genetic Lineages of Shiga Toxin-Producing Escherichia coli O157

• DOI: 10.1128/aem.06646-11
• 发表时间: 2012-05-01
• 期刊: APPLIED AND ENVIRONMENTAL MICROBIOLOGY
• 影响因子: 4.4
• 作者: Lee, Ken-ichi;French, Nigel P.;Kumagai, Susumu
• 通讯作者: Kumagai, Susumu

Emergence of a Novel Shiga Toxin-Producing Escherichia coli O Serogroup Cross-Reacting with Shigella boydii Type 10

• DOI: 10.1128/jcm.01197-11
• 发表时间: 2011-10-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Iguchi, Atsushi;Iyoda, Sunao;Ohnishi, Makoto
• 通讯作者: Ohnishi, Makoto

Lipopolysaccharide O-antigen of enterohemorrhagic Escherichia coli O157:H7 is required for killing both insects and mammals

• DOI: 10.1111/j.1574-6968.2012.02599.x
• 发表时间: 2012-08-01
• 期刊: FEMS MICROBIOLOGY LETTERS
• 影响因子: 2.1
• 作者: Miyashita, Atsushi;Iyoda, Sunao;Kaito, Chikara
• 通讯作者: Kaito, Chikara

Molecular Characterization Reveals Three Distinct Clonal Groups among Clinical Shiga Toxin-Producing Escherichia coli Strains of Serogroup O103

• DOI: 10.1128/jcm.00789-12
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Iguchi, Atsushi;Iyoda, Sunao;Ohnishi, Makoto
• 通讯作者: Ohnishi, Makoto