Analysis for role of bacterial cytoskeleton RodZ on virulence gene expression of Shigella type III secretion system

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Bacterial cytoskeleton RodZ was isolated as a factor affecting virulence gene expression of Shigella sonnei. Messenger RNA of the virulence gene was highly stabilized in the deletion mutant of rodZ gene and consistently purified RodZ protein bound to the RNA probe. Finding of amino-acids cluster essential for RNA binding indicated that RodZ has two distinct functions for RNA binding and cell-shape formation. We also found the membrane protein RodZ existed as homohexamer similar to another RNA binding protein Hfq.