Analysis of the mechanism of mature B cell differentiation controlled by survival signals from BCR and BAFF-R

来自BCR和BAFF-R的信号控制成熟B细胞的分化以及它们的存活。在本研究中，我研究了BCR和BAFF-R信号在成熟B细胞分化中的作用，发现PI 3激酶的靶分子之一Akt，其传递来自BCR的存活信号在B1细胞发育中起重要作用，并且经典NF-κ B途径在成熟B2和MZ B细胞产生中的主要功能是控制BAFF-κ B的强度。R介导的替代性NF-κ B信号传导。我还研究了一种新的泛素连接酶复合物LUBAC在B细胞中的功能，发现LUBAC在B1细胞的发育和抗体应答中起重要作用，并且是CD 40和TACI激活经典NF-κ B途径所必需的，而不是BCR。

Signals from BCR and BAFF-R control the differentiation of mature B cells as well as their survival. In this research I investigated the roles of signals from BCR and BAFF-R in the differentiation of mature B cells and found that Akt, one of the target molecule of PI3 kinase, which transmits the survival signal from BCR plays an important role in B1 cell development and that the main function of the canonical NF-kappaB pathway in the generation of mature B2 and MZ B cells is the control of the strength of BAFF-R mediated alternative NF-kappaB signaling. I also examined the function of a novel ubiquitin ligase complex, LUBAC in B cells and discovered that LUBAC plays important roles in the development of B1 cells and the antibody responses and is required for the activation of the canonical NF-kappaB pathway by CD40 and TACI but not by BCR.