Prevention of the onset of Graves' disease using high sensitivity method for TSH receptor antibody
Prevention of the onset of Graves' disease using high sensitivity method for TSH receptor antibody
批准号:
23590671
负责人:
HIDAKA YOH
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
关键词:
中文摘要
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英文摘要
We examined the correlation between the levels of TSH receptor antibody (TRAb) and cytokines in the supernatant incubated with the peripheral blood mononuclear cells (PBMCs) from the patients with Graves' disease in order to analyze the mechanism of onset of Graves' disease. However we could not find the correlation between the level of TRAb and cytokines.We tried to find the drugs that could suppress the production of TRAb in order to prevent the onset of Graves' disease. However the production of TRAb was not suppressed by anti-thyroid drug (methimazol) and anti-CD20 monoclonal antibody (rituximab).
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Different genotypes of a functional polymorphism of the TSHR gene are associated with the development and severity of Graves and Hashimotos diseases
TSHR 基因功能多态性的不同基因型与格雷夫斯病和桥本病的发生和严重程度相关
DOI:
10.1111/tan.12190
发表时间:
2013
期刊:
Tissue Antigen
影响因子:
--
作者:
[Inoue, N., Watanabe, M., Katsumata, Y., Hidaka, Y., Iwatani, Y]
通讯作者:
Y
Functional polymorphisms in TBX21 and HLX are associated with development and
TBX21 和 HLX 的功能多态性与发育和发育相关
DOI:
--
发表时间:
2012
期刊:
Autoimmunity
影响因子:
3.5
作者:
[Morita M, Watanabe M, Inoue N, Inaoka C, Akamizu T, Tatsumi K, Hidaka Y, Iwatani Y]
通讯作者:
Iwatani Y
無痛性甲状腺炎・亜急性甲状腺炎, 外来でどう診る?甲状腺疾患
无痛性甲状腺炎/亚急性甲状腺炎,门诊如何诊断?甲状腺疾病
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Junzo Nojima,Yukari Motoki, Hidehiro Tsuneoka, 日高洋]
通讯作者:
日高洋
Prolonged hybridization with a cRNA probe improves the signal to noise ratio for in-tube in situ hybridization for quantification of mRNA after fluorescence-activated cell sorting
与 cRNA 探针的长时间杂交可提高荧光激活细胞分选后用于定量 mRNA 的管内原位杂交的信噪比
DOI:
10.3109/10520295.2012.672650
发表时间:
2012
期刊:
Biotech Histochem
影响因子:
1.6
作者:
[Yamada, H., Yamakawa, N., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.]
通讯作者:
T.
自己免疫甲状腺疾患における病態とskewed X-chromosome inactivationとの関連
自身免疫性甲状腺疾病的病理学与 X 染色体倾斜失活之间的关系
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[石戸奈穂子, 井上直哉, 渡邉幹夫, 日高洋, 岩谷良則]
通讯作者:
岩谷良則
共 33 条
Establishment of preoperative molecular diagnostic methods for thyroid tumors
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批准号:20K07847
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2020
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负责人:HIDAKA YOH
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依托单位:
Pathological analysis of Graves' disease using highly sensitive thyroid stimulating antibody assay
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批准号:17K08982
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
-
财政年份:2017
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负责人:HIDAKA YOH
-
依托单位: