Behavioral study on analgesic effect of ATP sensitive potassium channel openers

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The analgesic effects of ATP sensitive potassium channel openers were examined using a rat neuropathic pain model. Chronic constriction injury to the sciatic nerve was induced in male Sprague–Dawley rats. Structurally distinct drugs, diazoxide, pinacidil, and nicorandil were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia. These drugs applied spinally and supraspinally attenuated mechanical and cold hyperalgesia in a dose-dependent manner, but they had no effect on thermal hyperalgesia. The ATP sensitive potassium channel openers may exert antihyperalgesic effects both in the spinal cord and brain.