Behavioral study on analgesic effect of ATP sensitive potassium channel openers

ATP敏感性钾通道开放剂镇痛作用的行为学研究

• 批准号: 23590732
• 负责人: HARANISHI Yasunori
• 金额: $ 3.41万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590732/
• 关键词: 行動薬理学; 鎮痛薬; 神経障害性疼痛; 脳室内投与; Kチャネル開口薬; 髄腔内投与

The analgesic effects of ATP sensitive potassium channel openers were examined using a rat neuropathic pain model. Chronic constriction injury to the sciatic nerve was induced in male Sprague–Dawley rats. Structurally distinct drugs, diazoxide, pinacidil, and nicorandil were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia. These drugs applied spinally and supraspinally attenuated mechanical and cold hyperalgesia in a dose-dependent manner, but they had no effect on thermal hyperalgesia. The ATP sensitive potassium channel openers may exert antihyperalgesic effects both in the spinal cord and brain.

采用大鼠神经病理性疼痛模型研究ATP敏感性钾通道开放剂的镇痛作用。在雄性Sprague-Dawley大鼠中诱导坐骨神经的慢性压迫性损伤。结构不同的药物，二氮嗪，吡那地尔，尼可地尔鞘内或脑室内给药，以检查机械，热和冷痛觉过敏的中枢作用。这些药物以剂量依赖的方式应用于脊髓和棘上衰减机械和冷痛觉过敏，但它们对热痛觉过敏没有影响。ATP敏感性钾通道开放剂可能在脊髓和脑中发挥抗痛觉过敏作用。

项目成果

Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain

• DOI: 10.1007/s00726-011-1094-9
• 发表时间: 2012-07-01
• 期刊: AMINO ACIDS
• 影响因子: 3.5
• 作者: Hara, Koji;Nakamura, Motohiro;Sata, Takeyoshi
• 通讯作者: Sata, Takeyoshi