Pathogenesis of chemical sensitivity as seen from the respiratory secretions response to TRPV-1 activity

为了阐明“化学敏感性”的发病机制，我们从呼吸道的先天生物防御反应——呼吸道分泌物的关系来探讨其发病机制。我们通过有害刺激敏感受体TRPV-1（瞬时受体电位，香兰素亚家族成员1）的呼吸道分泌物，估计其是呼吸道暴露刺激敏感部位，并利用光学方法测量气道分泌物，以探讨MCS患者的防御机制。我们的结果可以解释为，将TRPV1的激动剂辣椒素（10uM）添加到粘膜侧轻度增加气道分泌，并且在暴露于福尔马林（20ppm） 30-60min的气道粘膜中暂时升高。这些数据提示MCS患者气道分泌暂时升高的可能性。

For the purpose of elucidate the pathogenesis of "chemical sensitivity", we have examined it by the relationship to the respiratory secretions that is innate biological defense reaction of the respiratory tract. We have focused on respiratory secretions through the noxious stimuli-sensitive receptor TRPV-1(transient receptor potential, vanilloid subfamily member 1), which is estimated to be exposed-stimulation sensitive site in the respiratory tract and used optical methods to measure the airway secretion for investigating the defense mechanism of MCS patients.Our consequence would be explained that the addition of capsaicin (10uM), which is the agonist of TRPV1, to the mucosal side mild increased airway secretion and it is elevated temporarily in the airway mucosa that is exposed formalin (20ppm) for 30-60min.These data suggest the possibility of airway secretion is elevated temporarily in MCS patients.