Pathogenesis of chemical sensitivity as seen from the respiratory secretions response to TRPV-1 activity

为了阐明“化学敏感性”的发病机制，我们从呼吸道固有的生物防御反应--呼吸分泌物的角度对其进行了研究。我们已经通过有害刺激敏感受体TRPV-1关注呼吸道分泌物（瞬时受体电位，香草素亚家族成员1），该受体电位被认为是呼吸道暴露刺激敏感部位，并采用光学方法测量气道分泌以研究MCS患者的防御机制。我们的结果将解释添加辣椒素（10 μ M），TRPV 1激动剂对气道分泌物的刺激作用，对气道分泌物的刺激作用较轻，而在暴露于福尔马林（20 ppm）30- 60分钟的气道粘膜中，TRPV 1的刺激作用可使气道分泌物暂时性升高，提示MCS患者气道分泌物可能暂时性升高。

For the purpose of elucidate the pathogenesis of "chemical sensitivity", we have examined it by the relationship to the respiratory secretions that is innate biological defense reaction of the respiratory tract. We have focused on respiratory secretions through the noxious stimuli-sensitive receptor TRPV-1(transient receptor potential, vanilloid subfamily member 1), which is estimated to be exposed-stimulation sensitive site in the respiratory tract and used optical methods to measure the airway secretion for investigating the defense mechanism of MCS patients.Our consequence would be explained that the addition of capsaicin (10uM), which is the agonist of TRPV1, to the mucosal side mild increased airway secretion and it is elevated temporarily in the airway mucosa that is exposed formalin (20ppm) for 30-60min.These data suggest the possibility of airway secretion is elevated temporarily in MCS patients.