The association of thigh muscle area and CT attenuation measured by CT with metabolic diseases

CT测量大腿肌肉面积及CT衰减与代谢性疾病的关系

• 批准号: 23590748
• 负责人: SATO KYOKO
• 金额: $ 3.33万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590748/
• 关键词: 疫学; 骨格筋; 代謝性疾患

We examined whether a single-slice thigh muscle area measured by computed tomography (CT) can be substituted for thigh muscle volume measured with contiguous magnetic resonance imaging scans. This validation study consisted of 57 subjects. Correlation between volume and area was strong (0.864, p<0.001).In our cohort study, we analyzed the association of thigh muscle area and CT attenuation measured by CT with metabolic diseases in 1366 men and women. In multivariate analyses, the elevated area per kg of body weight (area/weight) was associated with the low prevalence of impaired fasting glucose (IFG) or type 2 diabetes, high normal blood pressure (BP) or hypertension, and hypertriglyceridemia. The elevated CT attenuation was associated with the low prevalence of IFG or type 2 diabetes, high normal BP or hypertension, hypertriglyceridemia, and hypo-high-density lipoproteinemia. The elevated area/weight or CT attenuation was related with the low insulin resistance among men or women.

我们研究了计算机断层扫描（CT）测量的单片大腿肌肉面积是否可以代替连续磁共振成像扫描测量的大腿肌肉体积。本验证性研究包括57名受试者。体积与面积相关性较强（0.864,p<0.001）。在我们的队列研究中，我们分析了1366名男性和女性大腿肌肉面积和CT测量的CT衰减与代谢性疾病的关系。在多变量分析中，每公斤体重面积（面积/体重）升高与空腹血糖受损（IFG）或2型糖尿病、高正常血压（BP）或高血压和高甘油三酯血症的低患病率相关。升高的CT衰减与IFG或2型糖尿病的低患病率、高正常血压或高血压、高甘油三酯血症和低高密度脂蛋白血症有关。在男性或女性中，面积/体重升高或CT衰减与胰岛素抵抗低有关。

项目成果

Thigh Muscle Fat and Insulin Resistance : Rectus Femoris Muscle is More Strongly Associated with Insulin Resistance than Hamstring Muscle

大腿肌肉脂肪和胰岛素抵抗：股直肌比腿筋肌肉与胰岛素抵抗的相关性更强

• 发表时间: 2013
• 作者: Harada KH;Hitomi T;Niisoe T;Takenaka K;Kamiyama S;Watanabe T;Moon CS;Yang HR;Hung NN;Koizumi A;奥田紀久子 他;Kyoko Sato
• 通讯作者: Kyoko Sato