The association of thigh muscle area and CT attenuation measured by CT with metabolic diseases

我们研究了通过计算机断层扫描(CT)测量的单层大腿肌肉面积是否可以替代连续磁共振成像扫描测量的大腿肌肉体积。这项验证性研究包括57名受试者。体积和面积之间的相关性很强(0.864，p&lt；0.001)。在我们的队列研究中，我们分析了1366名男性和女性大腿肌肉面积和CT测量的CT强度与代谢性疾病的关系。在多变量分析中，每公斤体重(面积/体重)升高的面积与空腹血糖受损(IFG)或2型糖尿病、正常血压(BP)或高血压以及高甘油三酯血症的低患病率相关。CT密度升高与IFG或2型糖尿病患病率低、正常血压或高血压高、高甘油三酯血症和低高密度脂蛋白血症有关。面积/体重或CT衰减的升高与男性或女性胰岛素抵抗的降低有关。

We examined whether a single-slice thigh muscle area measured by computed tomography (CT) can be substituted for thigh muscle volume measured with contiguous magnetic resonance imaging scans. This validation study consisted of 57 subjects. Correlation between volume and area was strong (0.864, p<0.001).In our cohort study, we analyzed the association of thigh muscle area and CT attenuation measured by CT with metabolic diseases in 1366 men and women. In multivariate analyses, the elevated area per kg of body weight (area/weight) was associated with the low prevalence of impaired fasting glucose (IFG) or type 2 diabetes, high normal blood pressure (BP) or hypertension, and hypertriglyceridemia. The elevated CT attenuation was associated with the low prevalence of IFG or type 2 diabetes, high normal BP or hypertension, hypertriglyceridemia, and hypo-high-density lipoproteinemia. The elevated area/weight or CT attenuation was related with the low insulin resistance among men or women.