Epidemiological study on soluble Fas as a apoptotic factor and IGF-1 as a cellular growth factor in relation to hemorragic cerebrovascular diseases

为了研究日本人脑梗死、“细胞死亡”和无动脉硬化的出血性卒中之间的关系，对分别位于秋田、茨木和高知的3个社区的约9000人进行了巢式病例对照研究，这些社区是长期随访队列。 在1984年以后的随访中，发生了54例发病年龄在69岁及以下的病例。 本研究选择了54例患者和108例与患者居住地区、性别、年龄和随访时间相匹配的对照者，测定了卒中发病前采血制备的血清中sFas（作为卒中相关因子）和IGF-1（作为细胞生长因子），并储存在深冻器中。 总之，本研究表明，sFas没有接受的关系，但可能缺乏IGF-1是改善动脉瘤壁的脆性作为蛛网膜下腔出血的致病机制。

To investigate the relation between apoptpsis, 'cell death', and hemorrhagic stroke without arteriosclerosis among Japanese, a nested case-control study was conducted on approximately nine thousand persons lived in three communities which were long-term follow-up cohorts existed in Akita, Ibaraki, Kochi, respectively. During follow-up from1984, 54 incident cases whose onset age was 69 and below occurred. In this study, 54 cases and 108 controls matched with cases for living area, sex, age, and follow-up periods were selected, and sFas as an apoptosis-related factor and IGF-1 as a cellular growth factor were measured in sera prepared from blood collection before onset of stroke and stored in deep freezers. In conclusion, the present study suggests that sFas did not accept relation, but a possibility that lack of IGF-1 was improving the brittleness of the aneurysm wall of cerebral arteries as a pathogenic mechanism of subarachnoid hemorrhage.