Is osteoporosis and fragility fracture associated with atherosclerosis and an increased risk of cardiovascular diseases? : In the 15-year follow-up survey of random samples of the Japanese population.

在日本基于人群的骨质疏松症（JPOS）队列研究的15年随访期内，既往骨质疏松性骨折、骨矿物质密度值或骨转换标志物在有和无心血管事件的受试者之间无显著差异。在10年随访调查中，年龄小于65岁的女性在5年随访期间踝臂指数（ABI）的年度变化（ABI是动脉粥样硬化的指标之一）与同期全髋关节和股骨颈骨密度的年度变化显著正相关，与年龄、骨密度和ABI值无关。骨丢失可能与年龄小于65岁的女性动脉粥样硬化进展有关。

Previous osteoporotic fracture, bone mineral density values, or bone turnover markers did not differ significantly between subjects with and without cardiovascular events in 15-year follow-up period of the Japanese Population-based Osteoporosis (JPOS) Cohort Study. In women aged younger than 65 year old at the 10-year follow-up survey, an annual change of ankle brachial index (ABI) during 5-year follow-up which is one of the index of atherosclerosis was significantly and positively correlated with an annual change of bone mineral density at the total hip and femoral neck during the same period independently of age, bone mineral density, and ABI values. Bone loss may be associated with advancing in atherosclerosis in women aged younger than 65 year old.