Prospective study of association between high plasma fetuin-A levels and incident ischemic stroke

无论机制如何，胎球蛋白-A的升高与代谢综合征和高胆固醇血症相关，这是心血管疾病的强危险因素。事实上，许多临床研究报道了高胎球蛋白A水平的受试者中心血管疾病的高发病率。我们前瞻性地研究了高胎球蛋白A水平与我们队列中缺血性卒中的发生相关，我们还阐明了血浆胎球蛋白A作为日本普通队列中卒中危险因素的重要性。

Whatever the mechanisms are, elevations of fetuin-A were associated with metabolic syndrome and hypercholesterolemia, which are strong risk factors for cerebro-cardiovascular diseases. In fact, many clinical studies reported a high incidence of cerebro-cardiovascular diseases in subjects with high fetuin-A levels.We prospectively investigated that higher fetuin-A levels are related to incident ischemic stroke in our cohort, and we also elucidated the significance of plasma fetuin-A as a risk factor of the stroke in a general Japanese cohort.