Prospective study of association between high plasma fetuin-A levels and incident ischemic stroke

无论是什么机制，胎球蛋白-A的升高都与代谢综合征和高胆固醇血症有关，而代谢综合征和高胆固醇血症是脑血管疾病的强烈风险因素。事实上，许多临床研究报道了胎球蛋白-A水平高的人群中脑血管疾病的高发病率。我们前瞻性地调查了在我们的队列中，高水平的胎球蛋白-A与发生的缺血性卒中有关，我们还阐明了在一般的日本队列中，血浆胎蛋白-A作为中风的危险因素的重要性。

Whatever the mechanisms are, elevations of fetuin-A were associated with metabolic syndrome and hypercholesterolemia, which are strong risk factors for cerebro-cardiovascular diseases. In fact, many clinical studies reported a high incidence of cerebro-cardiovascular diseases in subjects with high fetuin-A levels.We prospectively investigated that higher fetuin-A levels are related to incident ischemic stroke in our cohort, and we also elucidated the significance of plasma fetuin-A as a risk factor of the stroke in a general Japanese cohort.